DOMUNI UNIVERSITAS

Issues in Genomic Research

Issues in Genomic Research

This course will explore some of the ethical and social issues in genomic research; Specific emphasis will be placed on incidental findings, as well as how to manage such findings/information when they arise within genomic research.

ECTS Credits: 3
Professor: Cornelius Ewuoso, OP

Issues in Genomic Research

Introduction

01 Background
02 Statement of Problem
03 Aim and Objectives

CHAPTER 1.  LITERATURE REVIEW

1.1 Genomic Medicine and Research
1.1.1 History of Genomic Research
1.1.2 Scope of Genomic Research

1.2 General Methods and Technologies for Genomic Research
1.2.1 Genome Sequencing
1.2.2 Genome-Wide Association Studies
1.2.3 Gene Expression Analysis and Epigenetics
1.2.4 Bioinformatics

1.3 General Issues on Information Management in Genomic Research
1.3.1 Legal Issues
1.3.2 Social Issues

CHAPTER 2. INCIDENTAL FINDINGS: CONCEPTUAL CLARIFICATION AND DEBATE

2.1 Research Context versus Clinical Context
2.1.1 Participant and Contributor
2.1.2 Research Results and Incidental Findings

2.2 Scope and Extent of Incidental Findings in Genomic Research
2.3 Incidental findings and the Inevitable Questions
2.3.1 Genomic Libertarians
2.3.2 Genomic Skeptics

CHAPTER 3. SYSTEMATIC REVIEW OF ATTITUDES, PRACTICES AND PERSPECTIVES ON INCIDENTAL FINDINGS MANAGEMENT

3.1 Method and Materials

3.2 Data Extraction Process

3.3 Result
3.3.1 Description of Incidental Findings
3.3.2 Incidental Finding Management Preference
3.3.3 Type and Conditions for Returning Incidental Findings
3.3.4 Factors and Impacts of Returning of Incidental Findings
3.3.5 Recipient of Incidental Findings
3.3.6 Who Should Return Findings?
3.3.7 Suggestions for Improving the Management of Incidental Findings
3.3.8 Limitation and Relevance of Study

CHAPTER 4. HERMENEUTIC DISCUSSION

4.1 Defining Phenomenology
4.1.1 Eidetic Phenomenological Reductionism
4.1.2 Transitioning to Hermeneutic Phenomenology
4.1.3 The Researcher as a Being-in-the World
4.1.4 The Hermeneutic Phenomenological Task

4.2 Explicating the Implicit: A Hermeneutic Phenomenological Unraveling

4.3 Impacts of Returning Incidental findings on Scientific Research

4.4 Resolving the Impasse: A Hermeneutic Phenomenological Proposal
Conclusion
References